Story fodder can be something unknown to the quantum physicist, astronomer, psychologist, or oneirologist (dream studier) – whatever you find fascinating.
This is exactly the approach taken by the authors of The Encyclopaedia of Ignorance. The book is an old collection of short essays, some of which have proven prophetic. What, the authors asked leading scientists, don’t you know in your field that you find the most intriguing? It just makes sense to start your fiction with the other man’s ignorance. Such is the space inviting imagination.
Fantasy writers might benefit from knowing that intelligence is now measured by how many conflicting bits of information one can hold in working memory. That bit of knowledge makes it easy to show-not-tell a character’s intelligence and why they relate to others the way they do.
With new discoveries coming like rain, it’s difficult for an author to know what it is that the reader does not know. Research, even a quick Google on minor points, can prevent tripping the reader out of the story with an obviously false fact. And, of course, y’gotta feel for any author who set their story in 2020 before knowing about the Covid.
Ignorance is a sci-fi goldmine, but only if the author ain’t ignorant.